Bischof: Bioheat and Mass Transfer Measurement and...
Oct
27
Mon 4:00 PM
When Monday, October 27, 2008
Time
4:00 PM - 5:00 PM
Where Tech M416
Contact Molly Scanlon
847-491-5586
Group McCormick-Colloquia Engineering Sciences and Applied Mathematics
Applied Math Colloquium
Title: Bioheat and Mass Transfer Measurement and Modeling in Cryobiology
Speaker: John C. Bischof, University of Minnesota
Abstract: Heat and mass transfer is used to selectively preserve or destroy cells and tissues in cryobiology. Cryo or biopreservation aims to suspend viable cells in a glassy or partially crystalline phase, while cryosurgery uses crystallization to destroy malignant or unwanted cells and tissues in the body. A variety of thermodynamic excursions (i.e. thermal, chemical, mechanical, etc.) occur during these applications thereby resulting in the desired selective preservation or destruction of cells and tissues. This talk will focus on the use of transport models to predict temperature and phase during cryogenic thermodynamic excursions in bulk biomaterials. Since models are dependent on input conditions, a discussion of the evolving biomaterial transport property database in the cryogenic regime will be given. To conclude, a connection of the thermodynamic outcome (temperature and phase) with biological outcome (cell viability) from freezing protocols will be given in the context of the latent heat of evolution in biomaterials.
Title: Bioheat and Mass Transfer Measurement and Modeling in Cryobiology
Speaker: John C. Bischof, University of Minnesota
Abstract: Heat and mass transfer is used to selectively preserve or destroy cells and tissues in cryobiology. Cryo or biopreservation aims to suspend viable cells in a glassy or partially crystalline phase, while cryosurgery uses crystallization to destroy malignant or unwanted cells and tissues in the body. A variety of thermodynamic excursions (i.e. thermal, chemical, mechanical, etc.) occur during these applications thereby resulting in the desired selective preservation or destruction of cells and tissues. This talk will focus on the use of transport models to predict temperature and phase during cryogenic thermodynamic excursions in bulk biomaterials. Since models are dependent on input conditions, a discussion of the evolving biomaterial transport property database in the cryogenic regime will be given. To conclude, a connection of the thermodynamic outcome (temperature and phase) with biological outcome (cell viability) from freezing protocols will be given in the context of the latent heat of evolution in biomaterials.
