BEGIN:VCALENDAR
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME;VALUE=TEXT:PlanIt Purple
VERSION:2.0
PRODID:-//PlanIt Purple//EN
BEGIN:VEVENT
STATUS:CONFIRMED
LAST-MODIFIED:20090216T105647
URL:http://www.northwestern.edu/nico/events/index.html#seminars
PRIORITY:0
CLASS:PUBLIC
UID:377101@northwestern.edu
SUMMARY:Wednesdays@NICO: Genetic Adaptations to Different Habitats and the Susceptibility to Common Diseases
DESCRIPTION:Anna Di Rienzo\, Human Genetics\, University of Chicago.    Evolutionary pressures due to variation in climate and diet influence  phenotypic variation among and within species and have been hypothesized to  influence variation in several human phenotypes including body shape and size  and pigmentation. We used genotype data for 61 populations (including  52 populations from the Human Genome Diversity Project panel) from  Illumina HumanHap650Y SNP arrays to detect signals of selection with climate  and subsistence variables on a genome-wide scale. We found an excess of  signals of selection for genic SNPs\, in general\, and non-synonymous SNPs\,  in particular. We leveraged results from genome-wide association studies  to investigate whether sets of SNPs implicated in complex phenotypes and  disease traits have been subject to spatially varying selection. We found  evidence for selection with climate on the sets of SNPs associated with  several traits\, including celiac disease\, prostate cancer and  skin pigmentation and with subsistence for type 2 diabetes and lipid  levels. NICO Coffee Hour will follow for questions\, networking\, and collaboration.   http://www.northwestern.edu/nico/events/index.html#seminars
DTSTART:20090218T120000
DTEND:20090218T140000
CREATED:20081126T000000
DTSTAMP:20081126T000000
SEQUENCE:0
LOCATION:Evanston
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END:VCALENDAR