Mar
7
Thu 4:00 PM

BME Seminar: Patrick Kiser: “Engineering Drug Delivery Systems against HIV”

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When: Thursday, March 7, 2013
4:00 PM - 5:00 PM  
Where: Technological Institute, LR2
2145 Sheridan Road  
Evanston, IL 60208 map it
Audience: - Faculty/Staff - Student - Public
Contact: Suzanne A. Olds   (847) 467-2369
Group: McCormick - Biomedical Engineering Department
Category: Academic
More Info

Patrick Kiser, PhD
Associate Professor
Department of Bioengineering
University of Utah

4:00 – 5:00PM, Tech LR2
Thursday, March 7th
Reception to follow, outside LR2

Title:
“Engineering Drug Delivery Systems against HIV”

Abstract:
Mitigation of the AIDS pandemic in low-income countries requires highly active prevention technologies that can intervene in HIV-1 sexual transmission and inactivate virions at the point of mucosal contact. I will update you on the work to create intravaginal rings to prevent sexual transmission of HIV. We recently reported the first intravaginal ring that provided sterilizing protection in macaques from 16 serial intravaginal challenges of simian HIV over 4 months. In more forward looking projects we are engineering synthetic polymer systems based on phenyl boronic acid derivatives to modulate virus, cell and drug transport in the female reproductive tract. We have shown these systems can act as synthetic carbohydrate binding agents that utilize multivalency to achieve nanomolar potency against the highly glycosylated envelope of HIV-1. We have combined these polymers into pH sensitive reversible gels that trap HIV virions, immunocytes and sperm cells. Ultimately, these technologies, to be biologically effective, must be inexpensive and sufficiently diverse to match the variety of personal preferences and cultural norms across a range of resource settings.