Description:

John T. Wilkins, MD, MS, FAHA

Assistant Professor of Cardiology and Preventive Medicine
Department of Preventive Medicine
Feinberg School of Medicine

Presentation Title:
Apolipoprotein A-I Proteoforms and Their Associations with HDL Function

Objectives:
We will discuss a novel and rapidly developing technology that allows for the characterization and quantification of structural variation (allelic variation and post-translational modification) of ​proteins present in biological samples. We will discuss the implications for the characterization of post-translational modifications to "-omics" and clinical research. Lastly, we will discuss some preliminary results from the CARDIA study that demonstrate associations between specific apolipoprotein A-I structural variants and HDL function. These data provide "proof of concept" that detailed characterization of protein structure may aid in the discovery of novel pathways that mediate cardiovascular health and disease.