Description:

TITLE: Using a Level Set to Model Multiple Myeloma Induced Bone Loss

ABSTRACT: We exhibit the role mathematics can play in the study of multiple myeloma and the attendant dysregulatedbone remodeling. We discuss our approach to the "local" interactions of the microenvironment (osteoclasts, osteoblasts, stromal cells) and the myeloma tumor cells. The local model is then embedded in a spatially explicit model, based on level set equations, to represent the system at larger spatial scales.

SPEAKER: Bruce Ayati, PhD
Bruce Ayati is an Associate Professor of Mathematics and Orthopaedics& Rehabilitation at the University of Iowa. His research program focuses on applying numerical mathematics to study multiple myeloma disease progression and skeletal involvement, and the cellular, biochemical, and biomechanical bases of osteoarthritis. He earned his Ph.D. in Mathematics from the University of Chicago.