Description:

Title: A Mathematical Model for the Anti-PD-1 and IL-27 Drugs in Cancer Treatment

Speaker: Dr. Kang-Ling Liao, Mathematical Biosciences Institute, The Ohio State University

Abstract: Anti-PD-1 and anti-PD-L1 drugs have recently received FDA approval, and these drugs are already showing great promise in clinical trials. Combining the anti-PD-1 with an immunotherapeutic drug achieves much better results than the immunotherapeutic drug alone. An important question is how much of an improvement is achieved by anti-PD-1. In this talk, I will address this question with a mathematical model in a special case where the immuno-therapeutic drug is IL-27. The model is composed of a system of PDEs, which include the relevant cells and cytokines. Our simulations not only fit qualitatively with the experimental results, but also show that anti-PD-1 could be a powerful agent to enhance the efficacy of IL-27. For example, if we increase anti-PD-1 by a certain percentage, we get twice more tumor reduction than if we increase IL-27 by the same percentage. 

-----

To subscribe to the Applied Mathematics Colloquia List send a message to seminar-join@esam.northwestern.edu