Description:

Amit Jairaman, Graduate Student

Store-Operated Calcium Signaling in Airway Epitheliumee

Store-operated CRAC channels are an important mechanism for generating Ca2+ signals in many non-excitable cell types but their functional roles in airway epithelial cells (AECs) is poorly defined. We show that CRAC channels are a major route of calcium entry in AECs and mediate the induction of key inflammatory mediators suggesting that CRAC  channels could be a key checkpoint in the regulation of inflammatory responses in the airway.

Lyndsey Anderson, Ph.D., Postdoctoral Fellow

Pharmacogenomics of Drug Interactions

The risk for drug-drug interactions and associated adverse reactions may be greater in the setting of genetically compromised drug metabolizing enzyme function. The goal of this study is to implement a novel approach to assess the impact of genetic variants on CYP450 metabolic capacity using a high-throughput platform (SAMDI) and to investigate the impact of genetic variants in the context of potential drug-drug interactions.