When:
Tuesday, May 26, 2015
7:30 AM - 8:30 AM CT
Where: 676 N. St. Clair Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student
Contact:
Melanie Michelle Mkrdichian
(312) 926-9405
Group: Department of Surgery - Research Events
Category: Lectures & Meetings
Presenter: Adam J.T. Schuldt, MD, PhD
Cardiovascular disease is the leading cause of death and stroke in developed countries. Long-term outcomes following treatments for severe atherosclerosis are limited by the development of neointimal hyperplasia leading to restenosis of the vessel. Thus, there is a need for better and more durable therapies to prevent restenosis after vascular interventions. Nitric oxide (NO) is a potent inhibitor of neointimal hyperplasia. While much is known about how NO regulates the arterial injury response, little is known about how NO may regulate stem cells in this process. The focus of my research is to elucidate the functional role of resident adventitial Sca-1+ progenitor cells in vascular injury by using genetic cell tracking methods that will allow us to determine how these cells behave in response to injury, and to determine how nitric oxide alters the fate of these cells. We hope that these studies may lead to the development of better, targeted therapeutic options to prevent restenosis following vascular interventions.