When:
Tuesday, October 20, 2015
12:00 PM - 1:00 PM CT
Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Lavanya Visvabharathy
31093
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Department of Microbiology-Immunology Seminar Series
"Commensal microbiota are known to be required for the elicitation of host Th17 responses, which may mediate autoimmune diseases. The IL-23 pathway dynamically regulates the abundance of certain commensals and maintains barrier function. Barrier disruption results in systemic dissemination of microbial products, which invokes the IL-23 pathway, with both beneficial and potentially deleterious consequences. Through induction of IL-22, IL-23 contributes to barrier repair, and through induction of the Th17 response, it aims to neutralize escaped commensal microbes. Thus, barrier disruption results in a pro-Th17 environment in which not only anti-microbial but also potentially anti-host Th17 cells can develop."
Nico Ghilhardi, PhD
Genentech
Hosts: IMPTG trainees