Northwestern Events Calendar

Mar
8
2016

Regulation of RIG-I-like receptor signaling by host factors and viral pathogens: Michaela Gack, PhD

When: Tuesday, March 8, 2016
12:00 PM - 1:00 PM CT

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs

Contact: Eva Gottwein   (312) 503-8230

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Microbiology-Immunology Seminar Series

"RIG-I and MDA5, commonly termed RIG-I-like receptors (RLRs), sense a wide range of RNA viruses and subsequently induce signaling that results in the production of type-I interferons and proinflammatory cytokines. Our ongoing studies highlight an important role of posttranslational modifications for regulating the antiviral activities of RLRs. Intriguingly, several viruses have evolved strategies to modulate the intricate posttranslational modification program of RLRs for escaping innate immune detection.I will present our recent findings on RLR regulation by host factors, and on the strategies used by viral pathogens to manipulate the regulatory networks in innate immunity."

Michaela Gack, PhD

University of Chicago

Host: Dr. Eva Gottwein

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