Description:

The Department of Pharmacology and Robert H. Lurie Comprehensive Cancer Center welcome our faculty candidate : 

Shideng Bao, Ph.D.
Professor
Department of Stem Cell Biology & Regenerative Medicine
Learner Research Institute, Cleveland Clinic

The following, is an overview of this seminar, as described by Dr. Bao:

Glioblastoma (GBM) is the most lethal and common type of primary brain tumor. GBM displays striking cellular hierarchy containing glioma stem cells (GSCs). GSCs are functionally defined by extensive self-renewal, multi-lineage potency and potent tumor propagation. As GSCs promote tumor angiogenesis including vascular pericyte formation, cancer invasion, therapeutic resistance and tumor recurrence, therapeutic targeting of GSCs may significantly improve GBM treatment. We have identified several key signaling regulators that control the self-renewal and tumorigenic potential of GSCs. Molecular targeting of GSCs through functional inhibition of the newly identified targets in preclinical studies will be discussed.