Northwestern Events Calendar

Sep
20
2016

Have NEC Coat, Will Travel: Structural Basis of Membrane Budding During Nuclear Egress in Herpesviruses: Katya Heldwein, PhD

When: Tuesday, September 20, 2016
12:00 PM - 1:00 PM CT

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Gregory Smith   (312) 503-3745

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Microbiology-Immunology Seminar Series

"The nuclear egress complex (NEC) of herpesviruses, essential for the exit of nascent capsids from the nucleus, is the only known viral or cellular protein complex that is associated with budding of the nuclear membrane. We discovered that HSV-1 NEC has an intrinsic ability to mediate budding and scission by reconstituting the budding process in vitro using purified NEC and synthetic liposomes. We further showed that the NEC forms a hexagonal lattice on the inner surface of the budded vesicles, determined the crystal structure of the NEC lattice, and proposed that formation of the lattice drives the budding process. Thus, the NEC is a complete, virus-encoded, membrane-budding machinery that operates by a novel mechanism and independently of cellular factors. These exciting results are transforming the way we think about how viruses manipulate host membranes."

Katya Heldwein, PhD

Tufts University School of Medicine

Host: Dr. Gregory Smith

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