When:
Tuesday, September 20, 2016
12:00 PM - 1:00 PM CT
Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Dr. Gregory Smith
(312) 503-3745
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Microbiology-Immunology Seminar Series
"The nuclear egress complex (NEC) of herpesviruses, essential for the exit of nascent capsids from the nucleus, is the only known viral or cellular protein complex that is associated with budding of the nuclear membrane. We discovered that HSV-1 NEC has an intrinsic ability to mediate budding and scission by reconstituting the budding process in vitro using purified NEC and synthetic liposomes. We further showed that the NEC forms a hexagonal lattice on the inner surface of the budded vesicles, determined the crystal structure of the NEC lattice, and proposed that formation of the lattice drives the budding process. Thus, the NEC is a complete, virus-encoded, membrane-budding machinery that operates by a novel mechanism and independently of cellular factors. These exciting results are transforming the way we think about how viruses manipulate host membranes."
Katya Heldwein, PhD
Tufts University School of Medicine
Host: Dr. Gregory Smith