When:
Thursday, October 13, 2016
11:00 AM - 12:00 PM CT
Where: Pancoe-NSUHS Life Sciences Pavilion, Abbott Auditorium, 2200 Campus Drive, Evanston, IL 60208 map it
Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students
Contact:
Penelope T. Johnson
(847) 467-7464
Group: Chemistry of Life Processes Institute
Category: Lectures & Meetings
Tanmay Lele, PhD, University of Florida
Title: Dynamic Mechanical Integration Between the Nucleus and the Cell: Where Physics Meets Biology
Abstract: The nucleus has a distinctive shape, characteristic of its cell type and tissue in vivo. Nuclear shape affects chromatin compaction and architecture. Additionally, abnormalities in nuclear shape are a hallmark of many human diseases. Yet, how nuclear shapes are established and maintained in cells and tissues is not well-understood. I will describe the discovery of a new mechanism in which dynamic changes in cell shape generate mechanical stresses that shape the nucleus. I will explore how such stresses may control gene expression and cell function.