When:
Tuesday, May 2, 2017
12:00 PM - 1:00 PM CT
Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Mark Manzano
(312) 503-3076
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Microbiology-Immunology Seminar Series
Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental studies had been published prior to 2016. Concomitant with its recent spread to countries in the Western Hemisphere, which was associated with reports of microcephaly, congenital malformations and Guillain-Barré syndrome, the pace of discovery of ZIKV biology has accelerated greatly. Within a short time period, we and others have established useful mouse and non-human primate disease models, and pre-clinical evaluation of therapeutics and vaccines has begun. Unexpectedly, ZIKV exhibits a broad tropism and persistence in body tissues and fluids, which contributes to the clinical manifestations and epidemiology that have been observed during the current epidemic. In this talk, I will focus on studies from my laboratory that generated mouse models of ZIKV infection and pathogenesis during pregnancy as well as in the male reproductive tract. I will cover the effects of gestational age on ZIKV pathogenesis in utero, analysis of tropism, and discuss novel approaches for counter-measures including therapeutic antibodies and vaccines.
Michael S. Diamond, MD, PhD
Washington University School of Medicine
Host: M-I Dept. Virology Graduate Students
Coordinator: Mark Manzano, Graduate Student