When:
Monday, December 18, 2017
4:00 PM - 5:00 PM CT
Where: Pancoe-NSUHS Life Sciences Pavilion, Abbott Auditorium, 2200 Campus Drive, Evanston, IL 60208 map it
Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students
Cost: Free
Contact:
Tiffany Leighton Ozmina
(847) 467-2303
Group: Chemistry of Life Processes Institute
Category: Lectures & Meetings
Assembly Line Biosynthesis of Polyketide Antibiotics
Abstract:
Many complex natural products, such as polyketide antibiotics, are synthesized by multi-enzyme systems that operate as assembly lines. Their apparently modular architecture has opened the door to engineering of new antibiotics by rationally manipulating the DNA encoding these megasynthases. Understanding the structures and mechanisms of these assembly lines represents a challenging and exciting frontier. Recent progress toward this goal will be discussed.