Northwestern University

Dec
18
Mon 4:00 PM

Seminar: Chaitan Khosla, PhD

When: Monday, December 18, 2017
4:00 PM - 5:00 PM  

Where: Pancoe-NSUHS Life Sciences Pavilion, Abbott Auditorium, 2200 Campus Drive, Evanston, IL 60208 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Cost: Free

Contact: Tiffany Leighton Ozmina   847.467.2303

Group: Chemistry of Life Processes Institute

Category: Lectures & Meetings

Description:

Assembly Line Biosynthesis of Polyketide Antibiotics

Abstract:
Many complex natural products, such as polyketide antibiotics, are synthesized by multi-enzyme systems that operate as assembly lines. Their apparently modular architecture has opened the door to engineering of new antibiotics by rationally manipulating the DNA encoding these megasynthases. Understanding the structures and mechanisms of these assembly lines represents a challenging and exciting frontier. Recent progress toward this goal will be discussed.

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