Northwestern University

Tue 12:00 PM

BIDS Seminar: Rosemary Braun, PhD, MPH - Faculty Research (TimeStamp: A Universal Method for Robust Detection of Circadian State from Gene Expression)

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When: Tuesday, March 27, 2018
12:00 PM - 1:00 PM  

Where: Arthur Rubloff Building, Lakeview Conference Room (11th Floor), 750 N Lake Shore Dr, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Lindsay Varasteh   312.503.1997

Group: Center for Data Science and Informatics (CDSI)

Category: Lectures & Meetings


Abstract: Determining the state of an individual's internal physiological clock has important implications for precision medicine, from diagnosing neurological disorders to optimizing drug delivery.  To be useful, such a test must be accurate, minimally burdensome to the patient, and robust to differences in patient protocols, sample collection, and assay technologies. TimeStamp is a novel machine--learning approach to predict physiological time based on gene expression in human blood.  A powerful feature is TimeStamp's generalizability, enabling it to be applied to samples from disparate studies and yield highly accurate results despite systematic differences between the studies.  This quality is unique amongst expression--based predictors, and addresses a major challenge in the development of reliable and clinically useful biomarker tests.

About BIDS: These talks include visiting lecturers, presentations on research by BIDS faculty and trainees, as well as presentations about informatics tools and resources to support research.

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