Description:

The Department of Microbiology-Immunology Seminar Series

"Control of Host mRNA Translation and its Impact on Herpesvirus Lifestyle Decisions”

Ian Mohr, PhD  / New York University

Description

Two vignettes illustrating the impact of host mRNA translation upon herpesvirus infection biology will be presented. First, the way in which the host translational landscape changes in response to acute cytomegalovirus infection and regulates virus reproduction will be discussed. Next, a role for host mRNA translation in regulating herpes simplex virus latency in neurons will be described. Ongoing host protein synthesis provides a window into host physiology and homeostasis, and stress-induced changes trigger reactivation of latent herpes simplex virus infections.