When:
Tuesday, April 24, 2018
12:00 PM - 1:00 PM CT
Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Karla Satchell, PhD
(312) 503-2162
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Department of Microbiology-Immunology Seminar Series
"The Prokaryotic Pathogen’s Toolkit to Meddle with Host Ubiquitination"
Alexei Savchenko, PhD / University of Calgary
Description:
Ubiquitination is conserved eukaryote-specific signalling cascade culminating in the attachment of one or multiple copies of a small protein called ubiquitin to a target protein. Depending on the nature of ubiquitin modification arrangement it triggers either proteasomal degradation or a change in activity of target protein serving as the major signal transduction mechanism. Though bacteria lack ubiquitination, many bacterial pathogens have evolved specific pathogenic factors, called “effectors”, that are secreted inside the host cell to effectively manipulate this process. Here we present our discovery and molecular characterisation of ubiquitination-manipulating effectors in the arsenal of pathogenic Escherichia coli and Legionella pneumophila.
Combined, our data reveals novel molecular mechanisms in pathogenic bacteria’s arsenal of host manipulation and highlights the complex regulatory mechanisms integral to bacteria’s pathogenic strategy.