Northwestern Events Calendar

May
14
2018

"Kinetic Models Describing the Activation and Modulation of NMDA Receptors"

When: Monday, May 14, 2018
4:00 PM - 5:00 PM CT

Where: Ward Building, Room 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: Alexa Nash   (312) 503-4893

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings

Description:

The Department of Pharmacology Seminar Series will be presented by Gabriela K. Popescu, PhD, Professor of Biochemistry at the Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, SUNY.

Abstract:

NMDA receptors are a diverse family of excitatory channels with critical roles in central synaptic transmission, development, and plasticity. At the simplest level, their activation consists of two steps: glutamate binding and channel opening. However, direct observations of NMDA receptor currents indicate that they activate along a more complex sequence of events and many more transition rates control the rise and fall of the synaptic current. In this presentation, I will describe the multi-step reaction mechanisms I developed, which explains comprehensively receptor behaviors over several time domains, recording resolutions, stimulation patterns, and modulatory influences. With this computational tool we can anticipate receptor responses at synaptic and extrasynaptic locations.

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