Northwestern University

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Feb
20
Tue 12:00 PM

BIDS Seminar: Deborah Winter, PhD - Faculty Research (Mapping the Gene Regulatory Networks of Macrophages in Rheumatoid Arthritis)

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When: Tuesday, February 20, 2018
12:00 PM - 1:00 PM  

Where: Arthur Rubloff Building, Lakeview Conference Room (11th Floor), 750 N Lake Shore Dr, Chicago, IL 60611 map it

Audience: - Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Lindsay Varasteh   312.503.1997

Group: Center for Data Science and Informatics (CDSI)

Category: Lectures & Meetings

Description:

The Winter Lab of Functional Genomics applies genomic approaches to study the role of immune cells in health and disease.  In particular, we are interested in mapping the gene regulatory networks (GRNs) of macrophages through computational modeling of their transcriptional and epigenomic landscape in response to different environments, challenges, and disease.  Our previous work has shown that macrophages are capable of adapting their GRNs in response to signals from their tissue of residence through the combined action of cell-type-specific and tissue-specific transcription factors.  We believe this process represents a general mechanism by which macrophages exhibit plasticity in health and disease.  This talk will describe our work to analyze the transcriptional profile of macrophages in the joint synovium during the course of arthritis.  These synovial macrophages have been shown to derive from different sources (either tissue-resident or bone-marrow-derived) and play opposing roles in the onset and resolution of joint inflammation.  Using a mouse model of induced arthritis, we compare the transcriptional dynamics of different sub-populations of synovial macrophages during the course of inflammation.  These results suggest that different populations are pre-programmed in their response to arthritis.  In parallel, we isolate macrophages from synovial tissue of rheumatoid arthritis (RA) patients obtained through minimally invasive ultrasound-guided biopsy.  These samples provide us with the unique opportunity to profile in vivo synovial macrophages in patients with active RA.  We find that the global gene expression of macrophages clusters RA patients into 2 major groups associated with disease severity.  In addition, patients express different combinations of co-regulated gene modules, which may explain heterogeneity in disease progression and treatment response.  Our next step is to build on these studies to form a cohesive model of the function of synovial macrophage in arthritis and use these results to better predict the efficacy of different treatments.

Feb
27
Tue 12:00 PM

BIDS Seminar Featuring Justin Starren, MD, PhD - Developing A Successful Informatics Research Grant

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When: Tuesday, February 27, 2018
12:00 PM - 1:00 PM  

Where: Arthur Rubloff Building, Lakeview Conference Room (11th Floor), 750 N Lake Shore Dr, Chicago, IL 60611 map it

Audience: - Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Lindsay Varasteh   312.503.1997

Group: Center for Data Science and Informatics (CDSI)

Category: Lectures & Meetings

Description:

The success in obtaining research funding depends on several aspects and, in particular, on the understanding and execution steps of effective grant writing. This talk will be the first of a series that will provide a broad overview on the grant writing process, with specific focus on informatics. Topics will include fundamentals of good grant writing, preparation of a grant application, funding mechanisms, roles and responsibilities of a principal investigator, how to interpret and respond to reviewer’s comments, analysis of reviews and strategies for response and re-application.  

Dr. Starren has served on multiple NIH, NSF, and DOD grant review panels. He has successfully competed as PI or Co-PI for over $100 million in research grants over his career.

Mar
6
Tue 12:00 PM

BIDS Seminar: Yuan Luo, PhD - Faculty Research (Using Machine Learning to Predict Laboratory Test Results)

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When: Tuesday, March 6, 2018
12:00 PM - 1:00 PM  

Where: Arthur Rubloff Building, Lakeview Conference Room (11th Floor), 750 N Lake Shore Dr, Chicago, IL 60611 map it

Audience: - Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Lindsay Varasteh   312.503.1997

Group: Center for Data Science and Informatics (CDSI)

Category: Lectures & Meetings

Description:

Clinical decision support that integrates multiple elements of laboratory data could be highly useful in enhancing laboratory diagnosis. Using the analyte ferritin in a proof-of-concept, we extracted clinical laboratory data from patient testing and applied a variety of machine learning algorithms to predict ferritin test result using the results from other tests. We show that predicted ferritin results may sometimes better reflect underlying iron status than measured ferritin. We next integrate temporality into predicting multi-variate analytes. We devise an algorithm alternating between cross sectional imputation and auto regressive imputation. We show modest performance improvement of the combined algorithm compared to either component alone.

Mar
13
Tue 12:00 PM

BIDS Seminar (CANCELLED Due to AMIA Joint Summit)

CANCELLED

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When: Tuesday, March 13, 2018
12:00 PM - 1:00 PM  

Where: Arthur Rubloff Building, Lakeview Conference Room (11th Floor), 750 N Lake Shore Dr, Chicago, IL 60611 map it

Audience: - Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Lindsay Varasteh   312.503.1997

Group: Center for Data Science and Informatics (CDSI)

Category: Lectures & Meetings

Description:

Please note that there will NOT be a BIDS Tuesdays Seminar event this week (3/13/18) due to the AMIA Joint Summit.  Stay tuned for more details about the next BIDS Seminar event on 3/20/18 featuring Richard Gershon, PhD!

Mar
20
Tue 12:00 PM

BIDS Seminar: Richard Gershon, PhD - Faculty Research (Creating and Integrating Technology Based Measurement Systems)

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When: Tuesday, March 20, 2018
12:00 PM - 1:00 PM  

Where: Arthur Rubloff Building, Lakeview Conference Room (11th Floor), 750 N Lake Shore Dr, Chicago, IL 60611 map it

Audience: - Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Lindsay Varasteh   312.503.1997

Group: Center for Data Science and Informatics (CDSI)

Category: Lectures & Meetings

Description:

Please see the Blue Jeans dial in information below for those who would like to join us remotely:

To join the Meeting:
https://bluejeans.com/615041969/7973

To join via Room System:
Meeting ID: 615041969
Participant Passcode: 7973

To join via phone:
1) Dial:
+1.408.740.7256 (United States)
+1.888.240.2560 (US Toll Free)
+1.408.317.9253 (Alternate number)
(see all numbers - http://bluejeans.com/numbers)
2) Enter Conference ID: 615041969
3) Enter Participant Passcode: 7973

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This session will talk about measurement informatics and how my work focuses at the intersection of modern testing theory with technology. This session will present a bit on modern measurement science which uses Computer Adaptive Testing (CAT) to shorten tests while often increasing test reliability to create measures which are typically much shorter and less expensive to the administer. As PI of numerous measure development and technology distribution grants and contracts, I have worked with teams to develop patient reported outcome measures (the Patient Reported Outcomes Measurement Information System - PROMIS) and performance measures (The NIH Toolbox for the Assessment of Neurological Behavior and Function), and how these measures are integrated into existing testing platforms, such as REDCap, and patient portals, including Epic, to make them accessible for researchers, clinicians and patients.

About BIDS: These talks include visiting lecturers, presentations on research by BIDS faculty and trainees, as well as presentations about informatics tools and resources to support research.