Northwestern University

Mar
27
Mon 4:00 PM

CLP Seminar Speaker: Jacqueline Barton, PhD

When: Monday, March 27, 2017
4:00 PM - 5:00 PM  

Where: Technological Institute, LR4, 2145 Sheridan Road, Evanston, IL 60208 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: Tiffany Leighton Ozmina   847.467.2303

Group: Chemistry of Life Processes Institute

Category: Academic

More Info

Description:

DNA Signaling
Venue: Tech LR4
In the Barton group, we examine the chemical and physical properties of DNA and the biological implications of those properties. Our research has shown that DNA is more than just the library of the cell, existing only to hold genetic information; on the contrary, DNA is a molecule rich in complexity and full of surprises.
Previously, the Barton group has shown that the overlapping π system of stacked DNA bases can mediate the transfer of electrical charge (electrons and holes) over long distances. This DNA-mediated charge transfer (DNA CT) occurs in a variety of sequence contexts and between various types of charge donors and acceptors, shows a shallow distance dependence, and is exquisitely sensitive to perturbations to the base stack such as chemical damage and base pair mismatches. (For recent reviews, please see Genereux and Barton, 2010; Genereux, Boal, and Barton, 2010; and Genereux and Barton, 2009.)

Our current research is focused in three areas:
Using the unique binding environment of DNA to develop specific probes for DNA mismatches and lesions
Examining the biological implications of DNA CT
Designing electrochemical devices which can be used to sense DNA damage or report on DNA and protein binding events

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