Description:

Northwestern University Feinberg School of Medicine
Division of Pulmonary & Critical Care Medicine Presents:

“Re-establishing coordinated cell fate decision-making in disease using small molecules”
Lawrence Lum, PhD
Associate Professor and Director of Basic Science
Harold C Simmons Comprehensive Cancer Center
University of Texas Southwestern Medical Center

Abstract:
The homeostatic renewal of adult tissues is dependent upon the orderly succession of aged or damaged cells with nascent cells. The corruption of signaling mechanisms that coordinate cell fate determination in disease frequently is a direct cause of morbidity and post-therapy sequelae that compromise the quality of living. Using small molecules that target intercellular communication, we are testing the hypothesis that chemical approaches could be used to restore homeostatic communal cell signaling to suppress cancerous growth and to promote tissue regeneration.