Northwestern University

May
2
Tue 12:00 PM

Using Mouse Models to Study the Pathogenesis and Immune Response to Zika Virus: Michael Diamond, MD, PhD

When: Tuesday, May 2, 2017
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Mark Manzano   312.503.3076

Group: Microbiology-Immunology Seminars

Category: Lectures & Meetings

Description:

Microbiology-Immunology Seminar Series

 

Although Zika virus (ZIKV) was isolated approximately 70 years ago, few experimental studies had been published prior to 2016. Concomitant with its recent spread to countries in the Western Hemisphere, which was associated with reports of microcephaly, congenital malformations and Guillain-Barré syndrome, the pace of discovery of ZIKV biology has accelerated greatly. Within a short time period, we and others have established useful mouse and non-human primate disease models, and pre-clinical evaluation of therapeutics and vaccines has begun. Unexpectedly, ZIKV exhibits a broad tropism and persistence in body tissues and fluids, which contributes to the clinical manifestations and epidemiology that have been observed during the current epidemic. In this talk, I will focus on studies from my laboratory that generated mouse models of ZIKV infection and pathogenesis during pregnancy as well as in the male reproductive tract. I will cover the effects of gestational age on ZIKV pathogenesis in utero, analysis of tropism, and discuss novel approaches for counter-measures including therapeutic antibodies and vaccines.

 

Michael S. Diamond, MD, PhD

Washington University School of Medicine

Host: M-I Dept. Virology Graduate Students

Coordinator: Mark Manzano, Graduate Student

 

 

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