Northwestern University

Jun
20
Tue 12:00 PM

Molecular Mechanisms of Varicella-zoster Virus Pathogenesis: Ann M. Arvin, MD

When: Tuesday, June 20, 2017
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Richard Longnecker   312.503.0467

Group: Microbiology-Immunology Seminars

Category: Lectures & Meetings

Description:

Patricia A. Spear Colloquium

Microbiology-Immunology Seminar Series

 Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and establishes latency in sensory ganglion neurons; VZV reactivation results in herpes zoster. The formation of polykaryocytes, induced by cell-cell fusion between fully differentiated host cells within the tissue microenvironment, is a hallmark of VZV pathogenesis in skin and ganglia. Analyzing the molecular mechanisms of VZV pathogenesis in the severe combined immunodeficiency mouse (SCID) model reveals the critical role of the glycoproteins gB and gH/gL in this process. VZV pathogenesis also depends on its tropism for T cells to support viral transport to skin, which is promoted by its capacity to trigger the phenotypic remodeling of both naïve and memory T cells.

 

Ann M. Arvin, MD

Stanford University

Host: Richard Longnecker, PhD

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