Northwestern University

Sep
27
Wed 12:00 PM

"Mediodorsal thalamic regulation of PFC-dependent behaviors via parvalbumin interneurons"

When: Wednesday, September 27, 2017
12:00 PM - 1:00 PM  

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Donna Daviston   312.503.1687

Group: Department of Physiology Seminars

Category: Lectures & Meetings

Description:

The department of Physiology welcomes Wen-Jun Gao, Ph.D., Professor, with the department of Neurobiology and Anatomy, Drexel University College of Medicine

Abstract

The mediodorsal (MD) thalamus plays a critical role in cognition through its extensive innervation of the medial prefrontal cortex (mPFC), but how the two structures cooperate at single-cell level to generate cognitive functions and other mPFC-dependent behaviors remains elusive. Here, we silenced rat MD activity, and evaluated GABAergic inhibition and E/I balance in PFC neurons, as well as cognition, social interaction, and anxiety. Our findings identified a pathway between the MD and mPFC PV interneurons that regulates E/I balance and a broad range of behaviors. Utilizing a novel pharmacogenetic tool, we demonstrated that PV interneurons represent a therapeutic tool for an entire sequelae of alterations in mPFC-dependent behaviors.

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