Description:

The Department of Pharmacology welcomes Dr. Stefan Feske, M.D., Associate Professor, Department of Pathology, New York University School of Medicine.

Abstract:

Our work focuses on signaling pathways in cells of the immune system, particularly store-operated calcium entry (SOCE), mediated by the calcium release–activated calcium (CRAC) channel, and other ion channels. We are investigating how CRAC channels are activated, how they affect cell physiology, and how calcium signals control immune function in the contexts of infection, autoimmunity, and cancer. We are also studying patients with inherited mutations in CRAC channel genes. We use mouse models with targeted deletions of CRAC channel genes and employ genetic screening to identify ion channels that control immune responses in health and disease.