Northwestern University

Feb
15
Thu 2:00 PM

BMG Seminar: Engineering Immunity with Nanotechnology - Gabe A. Kwong, PhD

When: Thursday, February 15, 2018
2:00 PM - 3:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Beverly Kirk   312.503.5217

Group: Biochemistry & Molecular Genetics Seminar Series

Category: Lectures & Meetings

Description:

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents:

Gabe A. Kwong, PhD
Assistant Professor, Biomedical Engineering
Principal Investigator, Laboratory for Synthetic Immunity
Georgia Institute of Technology and Emory University School of Medicine

Human health has been transformed by our ability to engineer immunity – from the pivotal development of the smallpox vaccine to the curative potential of recent cancer immunotherapies. These examples motivate our research program where we merge engineering tools with immunology, creating new biotechnologies to better detect and treat diseases like cancer, organ transplant rejection, and infection. In this seminar, we will broadly describe our research in three vignettes that all leverage advances from nanotechnology: profiling immune repertoires, noninvasive monitoring of immunological health, and engineering T cell based therapies. First, we will describe the development of dynamic antibody-DNA gates for massively multiplexed analysis and sorting of immune cells. Unlike fluorescence based methods, a cytometry framework built on DNA gates can be readily scaled to analyze immune repertoires, such as identifying immunodominant viral epitopes for vaccine design. Second, we are developing activity-based nanoparticles that sense antigen-specific T cell killing in vivo by producing an ultrasensitive signal in urine. In the context of organ transplants, these nanoparticles detect the onset of acute T cell rejection at an early stage when treatments are most effective. Lastly, we will share research where we engineer T cell therapies with thermal gene switches so that their cancer-killing activity can be remotely controlled using pulses of heat. We envision the applications of these technologies will shape an array of immunological systems, and will increase our understanding of the immune system and how it can be controlled in health and disease.

Add Event to Calendar

Add Event To My Group:

Please sign-in