Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department: Richard Sora

When: Tuesday, February 13, 2018
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Richard Longnecker   312.503.0467

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

More Info


The Department of Microbiology-Immunology Seminar Series

"Preventing Two Pathways of p27Kip1 Degradation Delays LMP2A/MYC-Driven Lymphomagenesis"

Richard Sora, Graduate Student, Lab of Richard Longnecker, PhD / Northwestern University


Determining the mechanism by which LMP2A signaling leads to p27 degradation in LMP2A/MYC-driven lymphoma can lead to targeted therapies aimed at maintaining normal p27 levels in patients. These data show that a loss of SCFSkp2-mediated p27 degradation combined with nuclear localization of p27 by expression of the S10A knock-in is the most effective method yet for preventing tumor growth in our LMP2A/λ-MYC model of lymphoma. We hypothesize that LMP2A signaling promotes the degradation of p27 by both of these pathways.





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