Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department: Demian Cazalla, PhD

When: Tuesday, March 27, 2018
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Eva Gottwein   312.503.8230

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

More Info


The Department of Microbiology-Immunology Seminar Series

"Lessons from Viruses: Novel Roles for Non-coding RNAs in the Regulation of Gene Expression"

Demian Cazalla, PhD / University of Utah


Herpesvirus saimiri is an oncogenic herpesvirus that expresses seven Sm-class non-coding RNAs of unknown function called HSURs. We have found that one of these HSURs (HSUR2) base-pairs with mRNAs and recruits two cellular miRNAs to repress the expression of its target mRNAs. Using this mechanism, this virus can inhibit apoptosis in infected cells. These results reveal a new function for Sm-class RNAs as regulators of gene expression after pre-mRNA processing, and uncover a previously unrecognized strategy used by herpesviruses to rewire cellular pathways to escape apoptosis.

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