Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department: Alexei Savchenko, PhD

When: Tuesday, April 24, 2018
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Karla Satchell, PhD   312.503.2162

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Department of Microbiology-Immunology Seminar Series

"The Prokaryotic Pathogen’s Toolkit to Meddle with Host Ubiquitination"

Alexei Savchenko, PhD / University of Calgary



Ubiquitination is conserved eukaryote-specific signalling cascade culminating in the attachment of one or multiple copies of a small protein called ubiquitin to a target protein. Depending on the nature of ubiquitin modification arrangement it triggers either proteasomal degradation or a change in activity of target protein serving as the major signal transduction mechanism. Though bacteria lack ubiquitination, many bacterial pathogens have evolved specific pathogenic factors, called “effectors”, that are secreted inside the host cell to effectively manipulate this process. Here we present our discovery and molecular characterisation of ubiquitination-manipulating effectors in the arsenal of pathogenic Escherichia coli and Legionella pneumophila.
Combined, our data reveals novel molecular mechanisms in pathogenic bacteria’s arsenal of host manipulation and highlights the complex regulatory mechanisms integral to bacteria’s pathogenic strategy.

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