Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department: Judy Lieberman, PhD

When: Tuesday, April 17, 2018
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Pablo Penaloza-MacMaster, PhD   312.503.0489

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Department of Microbiology-Immunology Seminar Series

“Sounding the Alarm and Putting Out the Fire:
New Mechanistic Insights into Immunity to Invasive Infection”

Judy Lieberman, MD, PhD / Harvard University


Recently we identified the mechanism responsible for pyroptosis, the inflammatory death triggered by inflammasome activation in response to invasive infections and danger signals. Pyroptosis and inflammatory cytokine release is mediated by pore formation by the N-terminal fragment of gasdermin D after gasdermin D is cleaved by inflammatory caspases. We also showed that this gasdermin fragment binds to and permeabilizes the membranes of intracellular bacteria, killing the very bacteria that trigger the inflammasome. Moreover the active fragment is released during pyroptosis and kills extracellular bacteria, but not bystander mammalian cells. Recent work has solved the structure of the gasdermin D pore assembled during pyroptosis and identified inhibitors of pore formation that might be useful for treating sepsis and inflammatory/autoimmune diseases.

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