Description:

Accelerated brain aging in kidney impairment with Sanaz Sedaghat

The brain has an extra-ordinary metabolic demand. Although it accounts for less than 5% of body weight, it consumes about 20% of total body oxygen and 25% of total body glucose. Hence, the brain structure and function is critically dependent on systemic and cerebral vascular system. The kidney is a key regulator of vascular homeostasis. Patients with advanced kidney disease are at a great risk for developing stroke and dementia. Recent evidence suggests that the kidney-brain link is not limited to patients with end stage renal disease (ESRD) and even subtle changes in kidney function can affect the brain. This presentation includes findings on the link between kidney function and brain neurovascular integrity at the population level. In addition, potential mechanisms and targets to preserve brain health in relation to kidney function will be discussed.