Description:

Thomas Snaddon, PhD
Assistant Professor of Chemistry
Department of Chemistry
Indiana University

"Enantioselective Chemical Synthesis Methods via Cooperative Catalysis: Design, Development and Application"

Abstract
Our laboratory has embraced cooperative catalysis as a general design framework for the design of enantioselective reactions. We have primarily focused on a construct that unites C1 ammonium enolates with transition metal electrophiles, which addresses key challenges associated with Lewis base turnover, the locus of enantiocontrol, and the preservation of enolizable stereocenters in the products. As the source of enantiocontrol acts independently of the metal, the versatility of this approach is such that the role and function of the metal center can be modified and tuned without harm to enantioselection. This seminar will describe our most recent efforts in enantioselective carbon–carbon bond formation as well as extrapolation of our strategy to the synthesis of enantioenriched amines. Selected examples of application in target synthesis will also be presented.

Co-sponsored by CMIDD & Department of Chemistry. This is a Chemical Biology and Drug Discovery Research Cluster event. Faculty host is Professor Karl Scheidt.