Northwestern University

Nov
12
Mon 4:00 PM

Dissection of Cardiomyopathy using Animal Models mediated by Adeno-associated Virus

When: Monday, November 12, 2018
4:00 PM - 5:00 PM  

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: Liz Barrera Murphy   312.503.4892

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings

Description:

The Department of Pharmacology welcomes Jianming Jiang, Ph.D., Assistant Professor, Department of Biochemistry & Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore.

Pathogenic variants in sarcomere genes cause the largest portion of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Dominant toxic gain-of-function or haploinsufficiency are suggested as disease mechanisms. Apart from typical treatments for broader cardiovascular disease, limited options are available for cardiomyopathy patients. Novel treatment development for cardiomyopathy is also limited due to lack of disease animal models and potential therapeutic targets. In this presentation, I will discuss an approach to develop DCM mouse models using adeno-associated virus. In addition, I will discuss modulation of downstream genes and how this will suppress the progress of DCM. Our findings demonstrate that DCM can be treated by therapeutically modulation of downstream signalling pathways.

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