When:
Thursday, November 29, 2018
4:00 PM - 5:00 PM CT
Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Dr. Laimonis Laimins
(312) 503-0648
Group: Department of Microbiology-Immunology Seminars/Events
Co-Sponsor:
Virology Club
Category: Lectures & Meetings
Special Microbiology-Immunology and Virology Club Seminar
Title: "Metabolic Requirements for KSHV Latency”
Michael Lagunoff Ph.D., Professor of Microbiology, University of Washington
Host: Laimonis Laimins, PhD
Summary:
The Lagunoff lab has found that Kaposi’s Sarcoma-herpesvirus latent infection dramatically alters the metabolic profile of infected endothelial cells, including inducing the Warburg effect (aerobic glycolysis), glutaminolysis and fatty acid synthesis. Importantly, they have found that many metabolic changes are required for the survival of latently infected cells. Recent work using more global screens has identified additional metabolic pathways required for latency that can be targeted by specific drugs.