When:
Wednesday, November 14, 2018
2:00 PM - 3:00 PM CT
Where: 676 N. St. Clair Street, 6th Floor Video Conference Room, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student
Cost: Free
Contact:
Lynnette Dangerfield
(312) 926-7636
Group: Department of Surgery - Research Events
Category: Lectures & Meetings
Katherine Hekman, MD, PhD
Vascular tissue derived from patient-specific induced pluripotent stem cells (iPSCs) suffers from premature replicative senescence, creating a significant barrier to the advancement of organ and tissue bio-engineering. Our data support the role of mitophagy in mediating cellular senescence of iPSC-derived ECs, and renders autophagy induction a target for attenuating senescence. Overcoming this premature senescence would enable a more durable supply of patient-specific ECs for diagnostic and therapeutic applications in a wide range of disease states.