Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department: Joseph C. Sun, PhD

When: Tuesday, January 29, 2019
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Chyung-Ru Wang   312.503.9748

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


"Epigenetic Control of Innate and Adaptive Lymphocyte Responses"

Speaker: Joseph C. Sun, PhD -Memorial Sloan Kettering Center, Weill Cornel Medical College

Host: Chyung-Ru Wang, PhD



Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrated that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and ‘memory’ NK cells possess distinct chromatin accessibility states, and that their epigenetic profiles reveal a ‘poised’ regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory.



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