Northwestern University

Tue 12:00 PM

Microbiology-Immunology Department: Thomas M. Krisite, PhD

When: Tuesday, March 12, 2019
12:00 PM - 1:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Laimonis Laimins   312.503.0648

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


"Transitions in Chromatin States Modulates Herpes Simplex Virus Infection, Latency, & Reactivation"

Speaker: Thomas M. Kristin, PhD - National Institute of Allergy & Infectious Diseases, NIH

Host: Laimonis Laimins, PhD


Despite the availability of antivirals, herpes simplex virus remains a widely prevalent pathogen responsible for recurrent oral and genital lesions, developmental and neurological issues in infected newborns, and viral-mediated blindness. Modulation of the epigenetic state of the HSV genome plays a critical role in determining the course of viral lytic infection, latency, and signal-mediated reactivation. The laboratory focuses on the mechanisms by which an essential cellular transcriptional coactivator and its associated complexes mediate dynamic transitions in herpes simplex virus-associated chromatin to promote initiation of lytic infection and reactivation from latency. We are also exploring the use of inhibitors that target specific epigenetic factors regulating HSV gene expression in order to modulate the state of the viral chromatin and thereby suppress infection, shedding, and reactivation from latency in vivo.

Add Event to Calendar

Add Event To My Group:

Please sign-in