Northwestern University

May
13
Mon 4:00 PM

The role of the ventral hippocampus projection to the medial prefrontal cortex in social memory, and its dysfunction in Rett syndrome

When: Monday, May 13, 2019
4:00 PM - 5:00 PM  

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students

Contact: Alexa Nash   312.503.4893

Group: Department of Pharmacology Seminars

Category: Lectures & Meetings

Description:

Lucas Pozzo-Miller, Ph.D.
Professor, Department of Neurobiology
Associate Director, Comprehensive Neuroscience Center
Co-Director, Neuroscience Graduate Theme, Graduate Biomedical Science
University of Alabama at Birmingham School of Medicine

Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC projection is hyperactive in the Mecp2 knockout mouse model of the autism spectrum disorder Rett syndrome, which has deficits in social memory. Long-term excitation of mPFC-projecting vHIP neurons in wild-type mice impaired social memory, whereas their long-term inhibition in Rett mice rescued social memory deficits. The extent of social memory improvement was negatively correlated with vHIP-evoked responses in mPFC slices, on a mouse-per-mouse basis. Acute manipulations of the vHIP-mPFC projection affected social memory in a region and behavior selective manner, suggesting that proper vHIP-mPFC signaling is necessary to recall social memories. In addition, we identified an altered pattern of vHIP innervation of mPFC neurons, and increased synaptic strength of vHIP inputs onto layer 5 pyramidal neurons as contributing factors of aberrant vHIP-mPFC signaling in Rett mice.

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