When:
Monday, April 1, 2019
12:00 PM - 1:00 PM CT
Where: Robert H Lurie Medical Research Center, Searle Room, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Public - Post Docs/Docs - Graduate Students
Contact:
Alexa Nash
(312) 503-4893
Group: Department of Pharmacology Seminars
Category: Lectures & Meetings
Joint Department of Pharmacology and Seizure Focus Forum Seminar
Alex Shcheglovitov, Ph.D.
Assistant Professor of Neurobiology & Anatomy
Adjunct Assistant Professor of Psychiatry and Bioengineering
University of Utah
"iPSC-derived cortical organoids for modeling human cortical development and disorders"
Abstract: Many human-specific disorders originate in the cerebral cortex. However, our understanding of the cellular and molecular mechanisms underlying human cortical development is very limited. In my lab, we study human cortical development and disorders using induced pluripotent stem cells (iPSCs) and iPSC-derived cortical organoids generated from healthy control individuals and patients with different genetic neurodevelopmental disorders associated with autism, intellectual disability, and epilepsy. In my presentation, I will describe our new method for generating cortical organoids and discuss our progress towards modeling SHANK3-deficiency in organoids. Genetic abnormalities in SHANK3 have been detected in many patients with autism, intellectual disability, and epilepsy.