Northwestern University

Mar
14
Thu 10:00 AM

BMG Seminar: Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation- Brian Freeman, PhD

When: Thursday, March 14, 2019
10:00 AM - 11:00 AM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Vanessa Hughes   312.503.5229

Group: Biochemistry & Molecular Genetics Seminar Series

Category: Lectures & Meetings

Description:

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents:

Brian Freeman, PhD
Professor of Cell and Developmental Biology
University of Illinois

The rapid movement of chromosome sites within interphase cells is critical for numerous pathways including RNA transcription and genome organization. Yet, a mechanism moving any DNA locus in reaction to gene activation had not been reported. Here, we outline a molecular chaperone dependent pathway relocating a gene locus in response to a cellular signal. Our presented data support a model in which a two-authentication system mobilizes a gene promoter through a dynamic network of polymeric nuclear actin. Transcription factor-dependent nucleation of a myosin motor propels the gene locus through the actin matrix and fidelity of the actin association is ensured by ARP-containing chromatin remodelers. As the Hsp90 chaperone biases the remodeler-actin interaction towards nucleosomes associated with the non-canonical histone H2A.Z, the pathway is focused on specified sites such as transcriptionally active genes. Together, the system provides a rapid and effective means to broadly yet selectively mobilize chromosome sites.

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