Northwestern University

Mar
11
Mon 2:00 PM

CANCELLED: Genotypes to phenotypes: Lessons from the human genome and transcriptome - Barbara Stranger, PhD

CANCELLED

When: Monday, March 11, 2019
2:00 PM - 3:00 PM  

Where: Robert H Lurie Medical Research Center, Baldwin Auditorium, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Michelle Mohney   312.503.5602

Group: Center for Genetic Medicine

Category: Lectures & Meetings

Description:

Barbara E. Stranger, PhD
Assistant Professor, Department of Medicine, Section of Genetic Medicine
Core Member, Institute for Genomics and Systems Biology
Fellow, Center for Translational Data Science
The University of Chicago

This talk will illustrate how knowledge of the human transcriptome can inform on genome function and complex trait variation. The lecture will include examples of the genetic basis of gene regulation, applications to immune-mediated phenotypes, and the effects of sex on transcriptional variation.

Dr. Barbara Stranger is an Assistant Professor in the Department of Genetic Medicine at the University of Chicago. In addition, she is a Faculty Fellow in the Institute for Genomics and Systems Biology and The Center for Translational Data Science. Her lab analyzes multi-dimensional human genomics data, particularly transcriptome data and genetic variation data, in the context of health and disease. She develops effective analytic approaches for large-scale analysis of functional genomics data, and applies systems biology methodologies to integrate data of different types to inform biology of complex traits. She is a member of the Analysis Working Group (AWG) of NIH’s Genotype-Tissue Expression (GTEx) project, and leads the Sex Differences Working Group within the GTEx AWG. Current projects in her laboratory focus on understanding mechanisms and consequences of sexual dimorphism in: 1) Genetic regulation of gene expression in GTEx, 2) Genetic regulation of protein expression in GTEx, 3) Genetic architecture of neuropsychiatric traits, and 4) Genetics and genomics of cancer and response to therapy. She has a longstanding interest in evolution, and also applies the tools and approaches of population and evolutionary genetics to her research areas.

 

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