Northwestern Events Calendar

May
6
2019

Microbiology-Immunology Department: Zhichao Fan, PhD

When: Monday, May 6, 2019
1:30 PM - 2:30 PM CT

Where: Ward Building, Ward 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Dr. Chyung-Ru Wang   (312) 503-9748

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title: Auto-Inhibitory Integrin Activation During Human Neutrophil Arrest

 

Speaker: Zhichao Fan, PhD,  La Jolla Institute of Immunology

Host: Chyung-Ru Wang, PhD

 

Topic:

Integrins are critical for leukocyte recruitment and functions in inflammation. Using advanced imaging techniques, I discovered an alternative pathway of integrin activation and an auto-inhibitor mechanism of leukocyte adhesion and inflammation. By super-resolution microscopy, I find unique patterns of integrin molecular orientations. Using high-throughput screening, I discovered small molecular drugs that keep integrins in the auto-inhibitory conformation, which have potentials in treating inflammatory diseases.

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