Description:

The Simpson Querrey Center for Epigenetics presents:

Michael Green, MD/PhD
Professor and Chair, Department of Molecular, Cell and Cancer Biology                            University of Massachusetts Medical School

Lecture Title: Functional Genomic Approaches to Discover New Strategies to Treat Cancer

Abstract: My laboratory is interested in understanding the molecular basis of human diseases—in particular cancer and certain rare genetic disorders—and identifying factors and regulatory pathways that can be therapeutically targeted to treat these conditions. In general our research focuses on identifying new factors and regulatory pathways that promote or prevent cancer, and modulating gene expression as a therapeutic approach. To pursue these interests we use transcription-based approaches, functional screens (such as genome-wide loss-of-function RNAi- and CRISPR-based genetic screens) and proteomics methods to identify new genes, proteins, and regulatory pathways that are the cause of or contribute to the disease state. In addition, we are interested in developing new gene therapy approaches for cancer and other diseases. In my seminar I will discuss two projects, both based upon using genome-wide loss-of-function screening, that have revealed potential new strategies to treat cancer.