Northwestern Events Calendar

Jan
10
2020

Department of Microbiology-Immunology: Edward M. Campbell, PhD

When: Friday, January 10, 2020
12:00 PM - 1:00 PM CT

Where: Simpson Querrey Biomedical Research Center, Squerrey Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Mojgan Navghavi   (312) 503-4294

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Seminar: The Virus Like Spread of Alpha-Synuclein and Other Amyloid Proteins

Speaker: Edward M. Campbell, PhD 

Professor
Department of Microbiology and Immunology
Stritch School of Medicine
Loyola University Chicago

Host: Mojgan Naghavi, PhD

Topic:

Recent studies have revealed that amyloid proteins associated with neurodegenerative diseases, such as alpha-synuclein, spread from cell to cell via a “prion-like” mechanism. Our studies observe that alpha-synuclein and other amyloid proteins behave like non-enveloped viruses following endocytosis to destabilize endosomal and lysosomal membranes. This vesicular damage induces damage to the lysosomal degradation system and drives inflammatory responses that are known to be central to pathology of Parkinson’s disease and other neurodegenerative diseases, suggesting that the virus like spread of amyloid proteins is central to disease pathogenesis. 
 

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