When:
Friday, January 10, 2020
12:00 PM - 1:00 PM CT
Where: Simpson Querrey Biomedical Research Center, Squerrey Auditorium, 303 E. Superior Street, Chicago, IL 60611 map it
Audience: Faculty/Staff - Post Docs/Docs - Graduate Students
Contact:
Dr. Mojgan Navghavi
(312) 503-4294
Group: Department of Microbiology-Immunology Seminars/Events
Category: Lectures & Meetings
Seminar: The Virus Like Spread of Alpha-Synuclein and Other Amyloid Proteins
Speaker: Edward M. Campbell, PhD
Professor
Department of Microbiology and Immunology
Stritch School of Medicine
Loyola University Chicago
Host: Mojgan Naghavi, PhD
Topic:
Recent studies have revealed that amyloid proteins associated with neurodegenerative diseases, such as alpha-synuclein, spread from cell to cell via a “prion-like” mechanism. Our studies observe that alpha-synuclein and other amyloid proteins behave like non-enveloped viruses following endocytosis to destabilize endosomal and lysosomal membranes. This vesicular damage induces damage to the lysosomal degradation system and drives inflammatory responses that are known to be central to pathology of Parkinson’s disease and other neurodegenerative diseases, suggesting that the virus like spread of amyloid proteins is central to disease pathogenesis.