Description:

Title: Metabolic Regulation of M. tuberculosis Infection

Speaker: Sarah Stanley, PhD / University of California, Berkeley

Host: Hank Seifert, PhD

Topic:

Macrophages serve the dual role as both the host cell for Mycobacterium tuberculosis (Mtb) infection, and the cell that is primarily responsible for controlling infection by activating microbicidal mechanisms that effectively kill bacteria. We found that metabolic shifts in the host cell are required for effective macrophage-based control of Mtb infection. Host cell metabolites regulate both the transcriptional response to infection and the range of nutrients available to Mtb. I will describe these mechanisms, and will also discuss new work on mechanisms used by Mtb to evade host cell responses.