Northwestern Events Calendar

Mar
5
2020

Department of Microbiology-Immunology:Marco Jost, PhD

When: Thursday, March 5, 2020
10:00 AM - 11:00 AM  

Where: Robert H Lurie Medical Research Center, Searle Seminar Room, 303 E. Superior, Chicago, IL 60611 map it

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Hank Seifert   312.503.9788

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings

Description:

Title: Harnessing CRISPR to Dissect the Molecular Logic of Host-Microbiota Communication

Speaker: Marco Jost, PhD / University of California, Berkeley

Host: Hank Seifert

Topic:

Sweeping efforts to map the human microbiome have revealed a staggering complexity of species and molecules, raising a basic question: how do our bodies sense and respond to this diversity in a nuanced manner? I will describe a potentially general solution to this question using the recognition of bacterial cell surface glycolipids by human immune cells as an example. By combining CRISPR screens in primary human dendritic cells and bacterial genetics, I determined that dendritic cells recognize lipopolysaccharide from the gut microbe Bacteroides thetaiotaomicron through combinatorial engagement of multiple receptors whose signaling is integrated to produce a tailored response. This combinatorial sensing mechanism could enable immune cells to parse complex chemical landscapes with a limited repertoire of receptors and could constitute a prominent theme in host-microbiota communication.

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