Northwestern Events Calendar

Feb
12
2020

CDB Seminar Series: "Engineering new assays to reveal the biological design of chromosome segregation machinery"

When: Wednesday, February 12, 2020
12:00 PM - 1:00 PM CT

Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it

Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students

Contact: Vanessa Gonzalez   (312) 503-7959

Group: Department of Cell and Developmental Biology

Category: Lectures & Meetings

Description:

 
CDB SEMINAR PRESENTATION:

Engineering new assays to reveal the biological design of chromosome segregation machinery

 

Ajit P. Joglekar, Ph.D.

Associate Professor

Cell and Developmental Biology, University of Michigan Medical School

   

Wednesday, February 12, 2020

12:00 – 1:00 p.m.

Ward 5-230, PHYSIOLOGY CONFERENCE ROOM

303 E. Chicago St

Chicago, Illinois

   

Coffee and cookies served promptly at 12:00pm

Abstract
I will describe work from my lab that seeks to understand the biological design of two cellular systems: the kinetochore and the mitotic checkpoint. The kinetochore is a complex protein machine that moves chromosomes during cell division, while the mitotic checkpoint uses a kinetochore-based signaling mechanism to delay cell division if one or more kinetochores are not properly attached to the mitotic spindle. Both systems have been studied extensively using the reductionist approach, but this information does not fully reveal the cellular ‘logic’ that dictates specific aspects of their design. I will discuss one study in particular that explains how the mitotic checkpoint maximizes the accuracy of chromosome segregation while also minimizing unnecessary delays in cell division. I will also indicate how this work provides the foundation for our goal of building synthetic chromosome segregation machines.

Host: Dr. Dileep Varma

Assistant Professor, Department of Cell and Developmental Biology 

Northwestern University, Feinberg School of Medicine

 

  
 
 

 
 
For more information please contact Vanessa Gonzalez, vanessa.g@northwestern.edu

 
 
 

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