When:
Wednesday, February 12, 2020
12:00 PM - 1:00 PM CT
Where: Ward Building, 5-230, 303 E. Chicago Avenue, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Vanessa Gonzalez
(312) 503-7959
Group: Department of Cell and Developmental Biology
Category: Lectures & Meetings
CDB SEMINAR PRESENTATION:
Engineering new assays to reveal the biological design of chromosome segregation machinery
Ajit P. Joglekar, Ph.D.
Associate Professor
Cell and Developmental Biology, University of Michigan Medical School
Wednesday, February 12, 2020
12:00 – 1:00 p.m.
Ward 5-230, PHYSIOLOGY CONFERENCE ROOM
303 E. Chicago St
Chicago, Illinois
Coffee and cookies served promptly at 12:00pm
Abstract
I will describe work from my lab that seeks to understand the biological design of two cellular systems: the kinetochore and the mitotic checkpoint. The kinetochore is a complex protein machine that moves chromosomes during cell division, while the mitotic checkpoint uses a kinetochore-based signaling mechanism to delay cell division if one or more kinetochores are not properly attached to the mitotic spindle. Both systems have been studied extensively using the reductionist approach, but this information does not fully reveal the cellular ‘logic’ that dictates specific aspects of their design. I will discuss one study in particular that explains how the mitotic checkpoint maximizes the accuracy of chromosome segregation while also minimizing unnecessary delays in cell division. I will also indicate how this work provides the foundation for our goal of building synthetic chromosome segregation machines.
Host: Dr. Dileep Varma
Assistant Professor, Department of Cell and Developmental Biology
Northwestern University, Feinberg School of Medicine
For more information please contact Vanessa Gonzalez, vanessa.g@northwestern.edu