CANCELLED
When:
Wednesday, March 25, 2020
10:00 AM - 11:00 AM CT
Where: Robert H Lurie Medical Research Center, Searle Seminar Room, 303 E. Superior, Chicago, IL 60611 map it
Audience: Faculty/Staff - Student - Post Docs/Docs - Graduate Students
Contact:
Chernise Bailey-Turner
Group: Department of Dermatology
Category: Lectures & Meetings
Department of Dermatology Special Lecture
Speaker: Cory Simpson, MD, PhD, FAAD
Clinical Instructor
Department of Dermatology
University of Pennsylvania
Perelman School of Medicine, Philadelphia
"Tapping the Potential of Mitochondria in Dermatology: Mitochondrial Dynamics Regulate Epidermal Differentiation"
Keratinocytes in the outermost epidermal layers undergo a unique differentiation process to form the cutaneous barrier, initiating wholesale organelle degradation to form tightly packed cornified cells. To better understand epidermal development, we coupled live microscopy with organotypic human epidermis to image single organelle dynamics during tissue morphogenesis with an emphasis on mitochondria. We found that keratinocytes initiate mitochondrial degradation via the autophagy receptor NIX and the membrane GTPase DRP1, both of which were essential to proper epidermal differentiation. Now, we aim to build on these findings to explore therapeutic approaches to modulate mitochondrial dynamics in the epidermis in order to optimize skin barrier function and restore tissue homeostasis in disease