Northwestern Events Calendar


Pablo Penaloza-MacMaster, PhD - Improving Adaptive Immunity During Viral Iinfection and Vaccination

When: Tuesday, August 25, 2020
12:00 PM - 1:00 PM Central

Where: Online
Webcast Link

Audience: Faculty/Staff - Post Docs/Docs - Graduate Students

Contact: Dr. Pablo Penaloza-MacMaster   312.503.5240

Group: Department of Microbiology-Immunology Seminars/Events

Category: Lectures & Meetings


Seminar Title: Improving Adaptive Immunity During Viral Infection and Vaccination

Speaker: Pablo Penaloza-MacMaster, PhD/ Assistant Professor, Dept. of Microbiology-Immunology


Type I interferons (IFN-I) are a major antiviral defense and are critical for the activation of the adaptive immune system. However, early viral clearance by IFN-I could limit antigen availability, which could in turn impinge upon the priming of the adaptive immune system. In this study, we hypothesized that transient IFN-I blockade could increase antigen presentation after acute viral infection or vaccination. To test this hypothesis, we immunized mice with viruses coadministered with a low dose of IFN-I receptor–blocking antibody to induce a short-term blockade of the IFN-I pathway. This induced a long-lasting enhancement of immunological memory and conferred improved protection upon subsequent reinfections. These findings demonstrate a novel mechanism by which IFN-I regulate immunological memory and provide insights for rational vaccine design. Lastly, we will show new data on novel strategies to improve immunotherapy for chronic viral infection and cancer.

Host: Chyung-Ru Wang, Professor, Dept. of Microbiology-Immunology

Zoom Link:

Meeting ID: 984 0873 9107

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